1. The zippers and zipper holds on this bag are simply the best I have ever encountered. After years of dealing with frustrating zippers on various "outdoor" equipment, I was so pleased to discover that the Kamber 22 incorporates zipper loops that are easy to manipulate with or without gloves, and especially important - with one hand! The small "convenience" pocket at the top of the bag (for cell phone, change, etc.) is easy to open and close with one hand - very convenient when on the go. Really, really well-designed in this regard.
2. Super versatile. Literally the perfect bag for everything from skiing to city touring to even business travel. As an added bonus, this bag does not have the ridiculous tendency to tip over backwards when you set it down at an upright angle. Maybe I'm the only one who has experienced this issue, but every other backpack I've owned would constantly fall over. This one is like a Russian doll. It just stays upright, where you set it down. I like that a lot.
3. Finally, the size is awesome. 22 is big enough for a change of clothes, snacks and water, but small enough that it just fits without ever being bulky. Of particular importance to me, this bag is slim - it doesn't puff out on the sides or the back like most of TNF's bags. Length-wise, it comes just to the small of my back, exactly where it should fam for an active bag. I'm 6' for reference.
4. Best backpack I have found yet, and I've owned a lot of them.